558
Séminaire du Département de chimie
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The mechanism of proton transfer between adjacent sites exposed to water
Menachem Gutman (univ. Tel-Aviv) 2 mars 2005 |
The surface of a protein, or a membrane, is spotted with a multitude of proton binding sites, some of which are only few Å apart. When a proton is released from one site, it propagates through the water taking a random walk under the bias of the local electrostatic potential determined by the distribution of the charges on the protein. Some of the released protons disperse in the bulk, but during the first few nanoseconds, the released proton can be trapped by encounter with nearby acceptor sites, resembling the scenario which corresponds with the time dependant Debye-Smoluchowski equation.
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| Menachem Gutman (univ. Tel-Aviv) Departement de biochimie de l’Universite de Tel-Aviv |